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Sublingual Immunotherapy (SLIT) Explained

Sublingual Immunotherapy

When we talk about allergies and their management, the first thing that often comes to mind is allergy shots or injections. However, for those who are averse to needles or find the regular visits to a doctor’s office inconvenient, there’s another effective option known as Sublingual Immunotherapy (SLIT)

Understanding Sublingual Immunotherapy (SLIT)

Sublingual Immunotherapy, commonly referred to as SLIT, is a method of allergy treatment that doesn’t involve injections. Instead, it utilizes a specially formulated allergen extract in the form of drops or tablets that are placed under the tongue. Over time, this exposure helps the body build a tolerance to specific allergens, reducing or even eliminating allergic reactions.

How Does SLIT Work?

The premise behind SLIT is quite straightforward. By introducing tiny amounts of an allergen to the body in a controlled manner, the immune system gradually becomes desensitized to it. Over time, the body learns not to react aggressively to the allergen, leading to a reduction in allergy symptoms.

The sublingual route, or under-the-tongue method, is chosen because the area beneath the tongue has a rich supply of immune cells. When the allergen extract is placed there, it is quickly absorbed into the bloodstream, initiating the immune response necessary for building tolerance.

Benefits of SLIT

  • Convenience: One of the most significant advantages of SLIT is its convenience. Since it doesn’t require injections, individuals can administer the treatment at home after receiving guidance from their healthcare provider.
  • Suitable for Allergies to Inhalants and Foods: SLIT is not limited to airborne allergens; it can also be used for food allergies. This makes it a versatile option for individuals with a range of allergic conditions.
  • Safety: SLIT has a favorable safety profile, making it suitable for both children and adults. Serious adverse reactions are rare, though some may experience mild oral itching or swelling, which usually resolves on its own.
  • Efficiency: Numerous studies have demonstrated the efficacy of SLIT in reducing allergy symptoms and the need for other allergy medications. Many patients experience lasting relief even after completing their SLIT regimen.
  • Non-invasive: For those wary of needles or medical procedures, SLIT offers a non-invasive alternative. The drops or tablets are simply placed under the tongue, making it a more comfortable option for many.

Is SLIT Right for You?

While SLIT offers numerous benefits, it’s essential to determine if it’s the right choice for your specific allergy needs. Here are a few considerations:

Allergen Specific

Sublingual Immunotherapy is primarily effective for individuals with allergic rhinitis caused by specific allergens, such as pollen, dust mites, or certain molds. It may not be suitable for all types of allergies.


SLIT is a long-term commitment. For optimal results, patients typically need to adhere to the treatment plan for several months to years, depending on their response and the allergens being targeted.


Before starting SLIT, you’ll need to consult with one of our providers here at North Atlanta ENT & Allergy. They will assess your allergies, determine the most appropriate treatment plan, and monitor your progress. Give us a call today at 770-292-3045 to schedule an appointment.

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